Bruker Topspin

1. Bruker Nmr Software Download
2. Bruker Topspin Commands

Introductory

• The Chemistry NMR facility no longer provides licenses to Bruker's TopSpin processing software, as it is now free for academic users. Go to Bruker's website for the license and download.
• The guides listed below are all for Bruker Avance consoles running TopSpin 3.0 or newer, except for one area in the Misc section.

Topspinplot.docx 09/2016 Plotting NMR Spectra with TOPSPIN-PLOT These notes provide a brief introduction to plotting NMR spectra with the BRUKER TOPSPIN-PLOT interactive plot program using TopSpin 3. Please see the handouts Introduction to the TOPSPIN program and 2D.

1D NMR

• Directly-detected 1D X-nucleus experiments (¹³C, ³¹P, ¹⁹F, ²⁹Si, etc) in TopSpin
  — Notes for Boron(¹¹B and ¹⁰B) NMR

• TopSpin is published by Bruker and is used both to run the spectrometers (as a back end to IconNMR, the front end that we use) and to process data 4. Varian data must be converted to Bruker format before TopSpin can view it 5.
• Instructions for Bruker Topspin NMR Acquisition and Processing. Log on and initiate your session in OpenInstrument using your JHED ID and password. Open Topspin software from the icon on the desktop. Prepare sample for insertion into magnet by putting your tube into the sample spinner and adjusting the height with the depth gauge.
• TopSpin is published by Bruker and is used both to run the spectrometers (as a back end to IconNMR, the front end that we use) and to process data 4. Varian data must be converted to Bruker format before TopSpin can view it 5.
• Microprocessors, the former one for Intel x86 and Bruker X32. XWIN-NMR stores the byte order corresponding to the acquisition data in the acquisition status parameter BYTORDA (in the file acqus), which may take on the value little or big. This allows XWIN-NMR (or other software packages) to convert the data to the cor.

Miscellaneous

More TopSpin 3.x Guides

Bruker Nmr Software Download

• CMC-se and CMC-assist Notes(Structure Elucidation & Structure Verification)

Other/Older Bruker Guides

2D NMR

• 2D NMR via TopSpin: cosy, cosylr, dqfcosy, tocsy, hsqc, hsqc-edited, hsqc-coupled, hmbc, noesy, roesy
• 2D NMR via IconNMR
  — cosy, cosylr, dqfcosy
  — tocsy, hsqc
  — hmbc

Bruker Topspin Commands

More Exps

• no-D ¹H and ¹³C NMR(use of non-deuterated solvents)
• Ligand Binding:
  — Saturation-Transfer Difference (STD)
  — CPMG

BrukerTopspin

The Bruker Topspin™ software allows acquisition, processing and analysis of 1, 2 or 3D NMR data, and printing and export of the spectra. Besides the spectrometers, the software is available for processing/plotting on the external Linux workstations in the NMR lab. The Software can also be installed and run on personal computers in the department. The Department has a five seat network license (Code Meter) or users can obtain a free academic license from Bruker. The current version used for processing is 3.6.2.

• Download Topspin™ from NMR Lab Website (login required):
  WindowsOsX Linux
• Download Topspin™ from the Bruker website (free account required):
  Topspin for WindowsTopspin for Mac OsXTopspin for Linux
• Request a free Academic License HERE

Bruker Topspin CMC-se

The Structure elucidation module of Topspin allows for the automatic assignment of known structures or the generation of proposed structures using 2D COSY, HSQC and HMBC spectra. Starting with the molecular sum formula, the CMC-se solution analyzes the molecular structure using a defined protocol of 1D and 2D NMR spectra by generating a correlation table. The spectra and correlations can be generated automatically or interactively.

1. Bruker Nmr Software Download
2. Bruker Topspin Commands

Introductory

• The Chemistry NMR facility no longer provides licenses to Bruker's TopSpin processing software, as it is now free for academic users. Go to Bruker's website for the license and download.
• The guides listed below are all for Bruker Avance consoles running TopSpin 3.0 or newer, except for one area in the Misc section.

Topspinplot.docx 09/2016 Plotting NMR Spectra with TOPSPIN-PLOT These notes provide a brief introduction to plotting NMR spectra with the BRUKER TOPSPIN-PLOT interactive plot program using TopSpin 3. Please see the handouts Introduction to the TOPSPIN program and 2D.

1D NMR

• Directly-detected 1D X-nucleus experiments (¹³C, ³¹P, ¹⁹F, ²⁹Si, etc) in TopSpin
  — Notes for Boron(¹¹B and ¹⁰B) NMR

• TopSpin is published by Bruker and is used both to run the spectrometers (as a back end to IconNMR, the front end that we use) and to process data 4. Varian data must be converted to Bruker format before TopSpin can view it 5.
• Instructions for Bruker Topspin NMR Acquisition and Processing. Log on and initiate your session in OpenInstrument using your JHED ID and password. Open Topspin software from the icon on the desktop. Prepare sample for insertion into magnet by putting your tube into the sample spinner and adjusting the height with the depth gauge.
• TopSpin is published by Bruker and is used both to run the spectrometers (as a back end to IconNMR, the front end that we use) and to process data 4. Varian data must be converted to Bruker format before TopSpin can view it 5.
• Microprocessors, the former one for Intel x86 and Bruker X32. XWIN-NMR stores the byte order corresponding to the acquisition data in the acquisition status parameter BYTORDA (in the file acqus), which may take on the value little or big. This allows XWIN-NMR (or other software packages) to convert the data to the cor.

Miscellaneous

More TopSpin 3.x Guides

Bruker Nmr Software Download

• CMC-se and CMC-assist Notes(Structure Elucidation & Structure Verification)

Other/Older Bruker Guides

2D NMR

• 2D NMR via TopSpin: cosy, cosylr, dqfcosy, tocsy, hsqc, hsqc-edited, hsqc-coupled, hmbc, noesy, roesy
• 2D NMR via IconNMR
  — cosy, cosylr, dqfcosy
  — tocsy, hsqc
  — hmbc

Bruker Topspin Commands

More Exps

• no-D ¹H and ¹³C NMR(use of non-deuterated solvents)
• Ligand Binding:
  — Saturation-Transfer Difference (STD)
  — CPMG

BrukerTopspin

The Bruker Topspin™ software allows acquisition, processing and analysis of 1, 2 or 3D NMR data, and printing and export of the spectra. Besides the spectrometers, the software is available for processing/plotting on the external Linux workstations in the NMR lab. The Software can also be installed and run on personal computers in the department. The Department has a five seat network license (Code Meter) or users can obtain a free academic license from Bruker. The current version used for processing is 3.6.2.

• Download Topspin™ from NMR Lab Website (login required):
  WindowsOsX Linux
• Download Topspin™ from the Bruker website (free account required):
  Topspin for WindowsTopspin for Mac OsXTopspin for Linux
• Request a free Academic License HERE

Bruker Topspin CMC-se

The Structure elucidation module of Topspin allows for the automatic assignment of known structures or the generation of proposed structures using 2D COSY, HSQC and HMBC spectra. Starting with the molecular sum formula, the CMC-se solution analyzes the molecular structure using a defined protocol of 1D and 2D NMR spectra by generating a correlation table. The spectra and correlations can be generated automatically or interactively.

The module is part of the main Topspin software installation, but requires a separate license. The free academic version comes with a 'Classroom Licsence' that allows for peak picking and display and management of the assignment tables, but not for the automated assignment and structure generation.

The Department has currently one network license for the full funtionality that can be used by departmental users.